산학협력단

연구소장 소개

안녕하십니까? 바이오헬스융합연구센터를 방문해 주셔서 감사합니다.

연구소장 박명환

• •성명 : 박명환
• •이메일 : mpark@syu.ac.kr
• •소속 : 화학생명과학과
• •연락처 : 02-3399-1714(연구소), 1704(사무실)

학력

경력 및 수상

주요 연구분야

• 1. 나노입자와 고분자를 활용한 표면개질과 패터닝
• 2. 스마트 나노소재를 활용한 주문형 약물전달 시스템 개발
• 3. 바이오/환경 센싱을 위한 장치 및 시스템 개발
• 4. 마이크로/나노소재를 활용한 저마찰용 베어링 소재 개발
• 5. (초)미세버블을 활용한 산업소재 및 의약품 개발

특허(등록)

• 1. M.-H. Park, “나노버블과 약물이 함유된 약물담지체를 활용한 초음파 유도 약물전달시스템, Ultrasound-Assisted Delivery System using Microcapsule Platform Containing Nanobubbles and Drugs” (Application Number: 10-2019-0115941), (Patent Number: 10-2216549), (Registration Date: Fab. 09, 2021) (PCT Number: KR2019/012217), (Filing Date: Sep. 20, 2019), (US17/049,468, EP19863608.6 (EP3769751A), CN201980028332.1)
• 2. M.-H. Park, “약물 고정된 금속 막대입자를 활용한 근적외선 광열치료와 약물치료의 조합 항암치료 시스템, Combinational cancer therapy via near-IR responsive photothermal and chemotherapy with drug conjugated metal nanorods” (Application Number: 10-2018-0013897), (Filing Date: Sep. 21, 2018), (Patent Number: 10-2139601), (Registration Date: Jul. 24, 2020).
• 3. M.-H. Park, “순환종양세포 검출용 미세유체칩, MICROFLUIDIC CHIP FOR DETECTION OF CIRCULATING TUMOR CELLS OF CANCER CELLS” (Application Number: 10-2018-0011640), (Filing Date: Jan. 30, 2018) (Patent Number: 10-2029156), (Registration Date: Sep. 30, 2019)
• 4. M.-H. Park, “형광양자점을 함유하는 미세패턴 복합소재 제조방법, Fabrication of highly photoluminescent quantum dot-polymer composites” (Application Number: 10-2017-0131730), (Filing Date: Oct. 11, 2017), (Patent Number: 10-2091622), (Registration Date: Mar. 16, 2020)
• 5. M.-H. Park, “규소나노입자를 포함하는 미세유체칩 및 이를 포함하는 비색센서 및 이와 모바일앱을 이용한 비색센서 시스템, MICROFLUIDIC CHIP COMPRISING SILICONE NANOPARTICLE AND COLORIMETRIC SENSOR COMPRISING THEREOF AND COLORIMETRIC SENSOR SYSTEM USING MOBILE APP AND COLORIMETRIC SENSOR THEREOF”, (Application Number: 10-2017-0160848), (Filing Date: Nov. 28, 2017), (Patent Number: 10-2103582), (Registration Date: Apr. 16, 2020)
• 6. M.-H. Park, “감광성 나노복합체 및 이를 포함하는 약물 전달용 투과막, 및 이를 이용한 약물 전달 장치, PHOTORESPONSIVE NANOCOMPOSITE, MEMBRANE FOR DRUG DELIVERY COMPRISING THE SAME, AND DRUG DELIVERY DEVICE USING THE MEMBRANE”, (Application Number: 10-2016-0069685), (Filing Date: Jun. 03, 2016), (Patent Number: 10-1778698), (Registration Date: Sep. 08, 2017)
• 7. M.-H. Park, “SEBS/PP 복합소재의 물성 복원 방법 및 상기 방법에 의해 물성이 복원된 SEBS/PP 복합소재, METHOD FOR RECYCLING SEBS/PP COMPLEXS AND THE SEBS/PP COMPLEXS RECYCLED BY THE SAME”, (Application Number: 10-2015-0074688), (Filing Date: May 28, 2015), (Patent Number: 10-1684692), (Registration Date: Dec. 02, 2016)

특허(출원)

• 8. M.-H. Park, C. H. Cho, Y. G. Jung “나노버블 생성장치, Nano bubble generator” (Application Number: 10-2020-0118446), (Filing Date: Sep. 15, 2020)
• 9. M.-H. Park, “에스터 결합으로 약물이 고정된 리간드를 함유하는 초음파 조영제를 활용한 초음파 유도 약물전달체, Ultrasound guided drug delivery system using an ultrasonic contrast agent comprising ligands on which drugs are conjugated via ester bond” (Application Number: PCT/KR2020/ 011512, 10-2020-0108629, 10-2020-0108634, 10-2020-0108639), (Filing Date: Aug. 27, 2020)
• 10. M.-H. Park, and 7 others “오일젤 캡슐의 제조방법 및 오일젤 캡슐을 포함하는 차량용 접촉부품의 제조방법, A METHOD FOR MANUFACTURING OILGEL CAPSULES AND A METHOD FOR MANUFACTURING CONTACT PARTS FOR A VEHICLE INCLUDING THE OILGEL CAPSULES” (Application Number: 10-2019-0168352 & 10-2019-0168354), (Filing Date: Dec. 16, 2019) (US17/026,742, EP20205634.7, JP2020-193606, CN202011288981.6, US17/036,403, EP20204852.6, JP2020-193626, CN202011289057.X)
• 11. M.-H. Park, “나노버블수 생성장치, APPARATUS FOR PRODUCING NANO-BUBBLE WATER” (Application Number: 10-2019-0068228), (Filing Date: Jun. 10, 2019)
• 12. M.-H. Park, “에스터 결합으로 약물이 고정된 인지질을 사용하여 제조된 나노버블수를 활용한 초음파유도 약물전달체 및 이의 제조방법, Ultrasound-driven drug delivery platforms by the use of nanobubbles water prepared with drug-conjugated phospholipids via ester bonds and preparation method thereof” (Application Number: 10-2019-0024293), (Filing Date: Fab. 28, 2019)
• 13. M.-H. Park, S. J. Lee “나노버블이 함유된 약물담지체를 활용한 초음파 유도 약물전달 시스템, Ultrasound-Assisted Drug Delivery System Using Nanobubble-Contained Platform” (Application Number: 10-2018-0013896), (PCT Number: KR2018/011283), (Filing Date: Sep. 21, 2018)
• 14. M.-H. Park, “나노버블수를 이용한 나노입자의 제조방법”, Method for Preparing Nanoparticle Using Nanobubble Water” (Application Number: 10-2018-0013894), (Filing Date: Sep. 21, 2018)

논문(2016-present)

• 15. B. Jana, D. Kim, H. Choi, M. Kim, K. Kim, S. Kim, S. Jin, M.-H. Park, K. H. Lee, C. Yoon, B.-S. Lee, M.-S. Kang, H.-J. Lim, E.-J. Park, Y. Jeong, J.-H. Ryu, C. Kim “Drug resistance-free cytotoxic nanodrugs in composites for cancer therapy” J. Mater. Chem. B 2021, 9(5), ASAP
• 16. B. Singh, N. Shukla, C.-H. Cho, B. S. Kim, M.-H. Park,* K. Kim,* “Effect and application of micro- and nanobubbles in water purification” Toxicol. Environ. Health Sci. 2021 (Mar. 31), 13 (1), ASAP
• 17. G. Lim, K. Kim, Y. Park, M.-H. Park, “Development of Gold Nanoparticle Micropatterns for the Electrical Detection of Proteins” Nanomaterials. 2021, 11, ASAP
• 18. B. Singh, J. Lee, H. G. Kim, M.-H. Park,* K. Kim,* “Colorimetric detection of copper ions using porphyrin‑conjugated silica nanoparticles” Toxicol. Environ. Health Sci. 2020 (Dec. 31), 12 (4), 381-389.
• 19. N. Shukla, B. Singh, H.-J. Kim, M.-H. Park,* K. Kim,* “Combinational Chemotherapy and Photothermal Therapy Using a Gold Nanorod Platform for Cancer Treatment” Part. Part. Syst. Charact. 2020 37, 2000099.
• 20. B. Jana, S. Kim, H. Choi, S. Jin, K. Kim, M. Kim, H. Lee, K. H. Lee, J. Lee, M.-H. Park, Y. Jeong, J.-H. Ryu, C. Kim, “Supramolecular chemistry-mediated one-pot synthesis of cationic gold nanoparticles” J. Ind. Eng. Chem. 2020, 81, 303-308.
• 21. H. G. Kim, Y. W. Yu, Y. Yang, M.-H. Park, “Portable Environmental Microfluidic Chips with Colorimetric Sensors: Image Recognition and Visualization” Toxicol. Environ. Health Sci. 2019 (Dec. 31), 11 (4), 320-326.
• 22. D. Yoo, Y. Park, B. Cheon, M.-H. Park “Carbon dots as an effective fluorescent sensing platform for metal ion detection” Nanoscale Res. Lett. 2019 (Aug.13), 14, 272.
• 23. K. Kim, H. Choi, E. S. Choi, M.-H. Park,* J.-H. Ryu* “Hyaluronic Acid-Coated Nanomedicine for Targeted Cancer Therapy” Pharmaceutics 2019 (Jun.), 11(7), 301.
• 24. Y. Lu, H. Zhang, Z. Wang, S. Jeong, M.-C. Jo, M.-H. Park,* X. Duan,* “Real-time Detection of Nanoparticles Interaction with Lipid Membrane Using an Integrated Acoustical and Electrical Multimode Biosensor” Part. Part. Syst. Charact. 2019 (Feb.), 36(2), 1800370. Selected Cover Picture.
• 25. L. Palanikumar, J. Kim, J. Y. Oh, H. Choi, M.-H. Park,* C. Kim,* J.-H. Ryu,* “Hyaluronic Acid-Modified Polymeric Gatekeepers on Biodegradable Mesoporous Silica Nanoparticles for Targeted Cancer Therapy” ACS Biomater. Sci. Eng. 2018 (Mar. 29) 4(5) 1716-1722.
• 26. D.-M. Seon, Y. Park, G.-T. Yu, M.-H. Park,* J. Choi,* “Preparation of Organosilane Coatings via Chemically Pre-conjugated Graphene Oxides for Enhanced Dispersion and Hardness” Toxicol. Environ. Health Sci. 2018 (Mar.31), 10 (1), 72-78.
• 27. S. Yang, L. Palanikumar, S. Jeong, K. Kim, E. Jeoung, C. Kim, J.-H. Ryu, M.-H. Park, “Synergistic Effect of Photothermal Therapy and Chemotherapy using Camptothecin-conjugated Gold Nanorods” Part. Part. Syst. Charact. 2018 (Feb.), 35(2), 1700307.
• 28. S. Jeong, H. Park, D. Seon, J. Choi, K. B. Hong, J. Lee, C. Kim, J.-K. Kim, M.-H. Park, “Modulatory Functionalization of Gold Nanorods using Supramolecular Assemblies” Chem.-Asian J. 2017(Oct. 05), 12 (19), 2591-2596.
• 29. Y. Kim, H. S. Kim, Y. Yang, K. Baek, N. Choi, M.-H. Park, “Quantitative Analysis of Hydrogen Peroxide Using Ratiometric Fluorescent Probe-doped Silica Nanoparticles” Toxicol. Environ. Health Sci. 2017 (Jun.), 9 (2), 108-115.
• 30. L. Palanikumar, M. T. Jeena, K. Kim, J. Y. Oh, C. Kim, M.-H. Park,* J.-H. Ryu,* “Spatiotemporally and Sequentially-Controlled Drug Release from Polymer Gatekeeper–Hollow Silica Nanoparticles” Sci. Rep. 2017(Apr. 22), 7, 46540.
• 31. M.-H. Park, E. Reategui, W. Li, S. N. Tessier, K. H. K. Wong, A. E. Jensen, V. Thapar, D. Ting, M. Toner, S. L. Stott, P. T. Hammond, “Enhanced isolation and release of circulating tumor cells using nanoparticle binding in a microfluidic chip via ligand-exchange” J. Am. Chem. Soc. 2017(Feb. 22), 139(7), 2741-2749.
• 32. H. Park, S. Yang, J. Y. Kang, M.-H. Park, “On-demand drug delivery system using micro-organogels with gold nanorods” ACS Med. Chem. Lett. 2016 (Dec. 8), 7(12), 1087-1091.
• 33. C.-H. Kim, J.-H. Bang, K. B. Hong, M.-H. Park, “Fabrication of Highly Photoluminescent Quantum Dot-Polymer Composite Micropatterned Surface using Thiol-Ene Chemistry” RSC Advances 2016 (Oct. 03) 6 (99), 96700-96705.
• 34. K. Kim, M.-C. Jo, H. Park, L. Palanikumar, V. M. Rotello, J.-H. Ryu, M.-H. Park, “Externally controlled drug release using a gold nanorod contained composite membrane” Nanoscale 2016 (Jun. 21), 8 (23) 11949-11955.
• 35. J.-K. Kim, C.-H. Kim, M.-H. Park, “Effect of multiple recycling on the structure and morphology of SEBS/PP composites” B. Korean Chem. Soc. 2016 (Jun), 37 (6), 820-825.
• 36. Y. Jeong, S. T. Kim, B. Duncan, C. S. Kim, K. Saha, Y.-C. Yan, B. Yan, R. Tang, S. Hou, C. Kim, M.-H. Park, V. M. Rotello, “Nanoparticle-Dendrimer Hybrid Nanocapsules for Therapeutic Delivery” Nanomedicine 2016 (Jun.), 11 (12), 1571-1578.
• 37. J.-H. Bang, M.-H. Park,* H.-C. Ryu,* “A study on the photo-degradation properties of the spiropyran using THz-TDS” J. Korean Chem. Soc. 2016 (Fab), 60 (1), 28-33.

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