연구소장 소개

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연구소장 강태진

• •성명 : 강태진
• •이메일 : kangtj@syu.ac.kr
• •소속 : 삼육대학교 약학과 교수

학력

경력 및 수상

주요 연구분야

• •천연물 유래 생리활성물질을 활용한 신약 소재 개발 및 효능 연구
  • –신혈관생성을 촉진시키는 생리활성 물질 검색법 개발
  • –염증 조절 생리활성 물질 검색법 개발
• •아토피성 질환(아토피성 피부염, 천식) 치료제 개발을 위한 연구
  • –아토피성 피부염 및 기관지 천식 유발 기전 연구
  • –아토피성 질환 치료를 위한 천연 소재 생리활성 물질 효능 및 기전 검색 (in vivo & in vitro)
• •면역 능력 조절 치료제 개발에 대한 연구
  • –면역 조절 단백질 규명 및 그 기전 연구
  • –항염증 치료제 개발을 위한 염증 조절 기전 연구
  • –패혈증(Sepsis) 치료제 개발을 위한 생리활성 물질 기전 및 효능 연구
    – IL-1β & TNF-α 생성 조절 기전 및 그 기전에 관여하는 생리활성 물질 검색
• •천연 소재를 활용한 식․의약품 개발 관련 연구

논문

국제 전문 학술지

• •Kim TH, Chae GT, Kang TJ. The relation between NOD2 and IL-1β secretion in mouse tissues infected with Mycobacterium leprae. Cytokine, 2011 (Submitted)
• •Kang TJ, Moon JS, Lee SY, Yim DS, Polyacetylene Compound from Cirsium japonicum var. ussuriense inhibits the LPS-induced inflammatory reaction via suppression of NF-kB activity in RAW 264.7 cells Biomol & Ther. 2011; 19(1) (in press)
• •Lee GS, Choi JY, Choi YJ, Yim DS, Kang TJ*, Cheong JH*, The wound healing effect of Hydnocarpi Semen extract on ulcer in diabetic mice. Biomol & Ther. 2010; 18 (3): 329-335 * Co-corresponding authors
• •Kang TJ, Lee GS, Kim SK, Jin SH, Chae GT, Comparison of Two Mice Strains, A/J and C57BL/6, in Caspase-1 Activity and IL-1β Secretion of Macrophage to Mycobacterium leprae Infection. Mediators of Inflammation, vol. 2010, Article ID 708713, 5 pages, 2010. doi:10.1155/2010/708713 (Open Access Journal)
• •Kang TJ, Lee SY, Singh RP, Agarwal RA, Yim DS. Anti-tumore activity of oxypeucedanin from Ostericum koreanum against human prostate carcinoma DU145 cells. Acta Oncologica 2009; 48 (6): 895-900.
• •Li X-L, Ezelle HJ, Kang TJ, Zhang L, Shirey KA, Harro J, Hasday J, Mohapatra S, Crasta OR, Vogel SN, Cross AS, Hassel BA. An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity. PNAS. 2008; 105 (52): 20816-20821.
• •Chen WH, Kang TJ, Bhattacharjee AK, Cross AS. Intranasal administration of a detoxified endotoxin vaccine protects mice against heterologous Gram-negative bacterial pneumonia. Innate Immunity. 2008; 14 (5): 269-278.
• •Rifat S, Kang TJ, Mann D, Zhang L, Puche A, Stamatos NM, Goldblum SE, Brossmer R, Cross AS. Expression of sialyltransferase activity on intact human neutrophils. Journal of Leukocyte Biology. 2008; 84 (4): 1075-1081.
• •Kang TJ, Basu S, Zhang L, Thomas KE, Vogel SN, Baillie L, Cross AS. Bacillus anthracis spores and lethal toxin induce IL-1β via functionally distinct signaling pathways. European Journal of Immunology. 2008; 38 (6): 1574-1584.
• •Cole LE, Santiago A, Barry E, Kang TJ, Shirey KA, Roberts ZJ, Elkins KL, Cross AS, Vogel S. Macrophage Proinflammatory Response to Francisella tularensis Live Vaccine Strain Requires Coordination of Multiple Signaling Pathways. J. Immunol. 2008; 180 (10): 6885-6891.
• •Im JS, Kang TJ, Lee SB, Kim CH, Lee SH, Venkataswamy MM, Serfass ER, Chen B, Illarionov PA, Besra GS, Jacobs WR Jr., Chae GT, Porcelli SA, Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections. Clinical Immunology. 2008; 127 (2): 214-224.
• •Brahmbhatt TN, Darnell SC, Carvalho HM, Sanz P, Kang TJ, Bull RL, Rasmussen SB, Cross AS, O’Brien AD. Recombinant exosporium protein BclA of Bacillus anthracis effective as a booster for mice primed with suboptimal amounts of protective antigen. Infection and Immunity 2007; 75 (11): 5240-5247. (2007. 11)
• •Weaver J*, Kang TJ*, Raines K, Cao G, Baillie L, Rosen G, Cross AS. Protective Role of Bacillus anthracis Exosporium in Macrophage-Mediated Killing by Nitric Oxide. Infection and Immunity. 2007; 75 (8). 75 (8): 3894-3901* equally contributed
• •Basu S, Kang TJ, Chen WH, Fenton MJ, Baillie L, Hibbs S, Cross AS. Role of Bacillus anthracis (BA) Spore Structures in Macrophage Cytokine Responses. Infection and Immunity. 2007; 75(5): 2351-2358. )
• •Yeum CU, Park SY, Kang TJ, Han H, Chae GT. Effects of vitamin K2on adipogenic and osteogenic differentiation in mesenchymal stem cells from human umbilical cord blood. Key Engineering Materials. 2007; 342-343: 121-124.
• •Joshi VD, Kalvakolanu DV, Chen W, Zhang L, Kang TJ, Thomas TE, Vogel SN, Cross AS. A role for STAT1 in the regulation of lipopolysaccharide-induced interleukin-1β expression. Journal of Interferon and Cytokine Research. 2006; 26 (10): 739-747.
• •Raines KW, Kang TJ, Hibbs S, Cao GL, Weaver J, Tsai P, Baillie L, Cross AS, Rosen GM. Importance of Nitric Oxide Synthase in the Control of Infection by Bacillus anthracis. Infection and Immunity. 2006; 74(4): 2268-2276.
• •Kang TJ, Fenton MJ, Weiner MA, Hibbs S, Basu S, Baillie L, Cross AS: Murine macrophages kill the vegetative form of Bacillus anthracis. Infection and Immunity. 2005; 73(11): 7495-7501.
• •You EY, Kang TJ, Kim SK, Lee SB, Chae GT. Mutations in genes related to drug resistance in Mycobacterium leprae isolates from leprosy patients in Korea. Journal of Infection 2005; 50(1): 6-11.
• •Kang TJ, Yeum CE, Lee H, Rho SH, Han H, Chae GT. Growth kinetics of mesenchymal stem cells from bone marrow and umbilical cord blood. Acta Haematologica 2004; 112(4): 230-233.
• •Kang TJ, Yeum CE, Kim BC, You EY, Chae GT. Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation. Immunology. 2004; 112(4): 674-80.
• •Kim BC, Kang TJ, Yeom JE, Chae GT. Tissue-specific down-regulation of RIPK2 in Mycobacterium leprae infected nu/nu mice. Mediators of Inflammation. 2004; 13(1): 51-52
• •Kang TJ, Kim SK, Lee SB, Chae GT, Kim JP, Ko YH. Comparison of two different PCR amplification products (the 18 kDa Protein Gene vs. RLEP Repetitive Sequence) in the diagnosis of Mycobacterium leprae. Clinical and Experimental Dermatology. 2003; 28(4): 420-424
• •Lee SB, Kim BC, Jin SH, Park YG, Kim SK, Kang TJ, Chae GT. Missense mutation of the interleukin-12 receptor beta 1 (IL-12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea. Immunogenetics. 2003; 55(3): 177-181
• •Kim SK, Lee SB, Kang TJ, Chae GT. Detection of gene mutations related with drug resistance in Mycobacterium lepraefrom leprosy patients using Touch-Down (TD) PCR. FEMS Immunol. Med. Microbiol. 2003; 26(1-2): 27-32
• •Kang TJ, Lee SB, Chae GT. A polymorphism of TLR2 is associated with IL-12 production in lepromatous leprosy. Cytokine. 2002; 20(2): 56-62
• •Chae GT, Kim MJ, Kang TJ, Lee SB, Shin HK, Kim JP, Ko YH, Kim SH, and Kim NH. DNA PCR and RT-PCR for the 18kDa gene of Mycobacterium leprae to assess the efficacy of multi-drug therapy for leprosy. J. Med. Microbiol. 2002; 51(5): 417-422.
• •Chae GT, Lee SB, Kang TJ, Shin HK, Kim JP, Ko YH, Kim SH, and Kim NH. Typing of clinical isolates ofMycobacterium leprae and their distribution in Korea. Leprosy Review. 2002; 73(1): 41-46.
• •Kang TJ, You JC, Chae GT. Identification of catalase-like activity from Mycobacterium leprae and the relation between catalase and isonicotinic acid hydrazide(INH). J. Med. Microbiol. 2001; 50(8): 675-681.
• •Kang TJ, Chae GT. Detection of TLR2 mutation in lepromatous leprosy patients. FEMS Immunol. Med. Microbiol. 2001; 31(1): 53-58.
• •Lee SB, Kim SK, Kang TJ, Chae GT, Chun JH, Shin HK, Kim JP, Ko YH, and Kim NH. The prevalence of mutations in the folP1 gene of the Mycobacterium leprae in isolates from Korea in association with clinical resistance to Dapsone. Annals of Tropical Medicine and Parasitology. 2001; 95 (4): 419-432.

국내 전문 학술지

• •Lee GS, Pena ID, Choi JH, Choi JY, Yoon SY, Kang TJ, Oh SK, Cheong JH. Effect of SPZZC, a Composition of Herb Extracts, on Atopic Dermatitis in BALB/c and NC/Nga Mouse. Yakhak Hoeji. 2008; 52 (3): 232-239.
• •강태진. 알코올성 간질환과 자연면역반응. 한국알코올과학회지 2007; 8: 77-92
• •김병철, 강태진, 채규태. 나균 감염과 RIPK2의 연관성 연구. 대한나학회지 2003; 36(2): 23- 29.
• •김세곤, 강태진, 김병철, 채규태. 나균감염에 관련된 Phagosomal Coat Protein (TACO)의 C-terminal region (exon 9～11)의 point mutation. 대한나학회지 2003; 36(1): 11- 26.
• •이성범, 유은영, 김세곤, 강태진, 김종필, 고영훈, 채규태. 복합 항나제의 치료에 내성을 보이는 한국인 나환자에서 분리한 나균에서의 folP1, rpoB, gyrB 유전자의 돌연변이에 대한 연구. 대한나학회지 2003; 36(1): 3-9.
• •김세곤, 이성범, 강태진, 채규태. 나환자 진단 및 약제내성 검색에 있어서 TD-PCR의 적용. 대한나학회지 2001; 34(2): 13-21.
• •강태진, 이성범, 채규태. 나병병형에 따른 IL-12 생성에 미치는 TLR2 변이의 영향. 대한나학회지 2001; 34(2): 3-12.
• •강태진, 이성범, 채규태. 누드 마우스로부터 나균 세포추출물 분리를 위한 최적화 방법에 관한 연구. 대한나학회지. 2001; 34(1): 47-56.
• •채규태, 이성범, 강태진, 김종필, 고영훈. 한센병의 감수성 및 그 병형에 관련된 HLA-A,B 및 DRB1 유전자의 규명. 대한나학회지. 2000; 33(2): 67-78.
• •강태진, 채규태. Isonizid 활성에 있어서 Mycobacteria의 katG gene의 역할. 대한나학회지. 2000; 33(2): 55-66.
• •김세곤, 김민주, 강태진, 채규태. 나균감염 대식세포에서 Rifampin의 H2O2억제효과. 대한나학회지. 1997; 30(2): 41-48

저서

• •생리학 7판. 강영숙 외, (2011년) 라이프사이언스. ISBN : 9788961541022

주요 프로젝트

• •세포 내 병원균 감염에 대한 대식세포의 caspase-1 inflammasome 역할 규명
• •천연의 면역조절 기능성 소재를 이용한 아토피 피부염 화장료 개발
• •한방제제를 이용한 in vivo 아토피성 피부염 치료 효능 평가
• •염증성 여드름 치료용 조성물 개발
• •대풍자를 활용한 항궤양 및 창상 치료 신약 개발

보유장비

• •Clean bench (Biosafety II, Bio-free)
• •Microcentrifuge (Eppendorf)
• •Bench-top centrifuge (Gyrozen)
• •CO2 incubator (Sanyo)
• •Deep Freezer (초저온냉동고, Il-Shin)
• •Inverted Microscope (Olympus)
• •etc.